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cerevisiae , Arabidopsis thaliana and T98G glioblastoma cells when available GSH levels were critically depleted either through drug treatment or genetic manipulation [32],[33],[46]

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When these two compounds were incubated in the presence of 10 mM GSH for 6 or 18 h under physiological conditions before adding them into the in vitro kinase assay (PhALC), the IC 50 of JNK-IN-8 drastically dropped but 1a R -IN-8 stayed similarly active in blocking MAPK activity (Fig