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Deficiencies are common in people who have digestive imbalances or are over-stressed

Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Wu et al., 2016) and damages the cytoskeleton, along with other physiological processes related to insulin signaling

Methylated B vitamins address this directly and as the pathway diagram shows, adequate B12 and folate are also prerequisites for healthy cysteine production upstream of the glutathione system

This direct scavenging action is particularly crucial for protecting the central nervous system