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For instance, lnRNAs RP5-833A20.1 and E330013P60 are upregulated in foam cells and macrophages under hyperglycemic conditions, which increases the expression of inflammatory cytokines, including IL-1, IL-6, and TNF, and promotes pro-inflammatory macrophage phenotypes through mechanisms involving miR-382-5p induction and NFIA suppression [141]

Front Genet 13:1011659 Yao Y, Zhang H, Wang Z, Ding J, Wang S, Huang B, Ke S, Gao C (2019) Reactive oxygen species (ROS)-responsive biomaterials mediate tissue microenvironments and tissue regeneration

It has been demonstrated that metformin treatment can promote FGSC proliferation and facilitate follicular maturation, thus enhancing ovarian reserve capabilities ( There exists abnormal GC damage in the ovary of POF patients (Lin et al., 2022)

A position statement of the World Obesity Federation

Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, et al: Metabolic gene polymorphism frequencies in control populations

Lee, University of North Carolina at Chapel Hill, United States