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Recently, non-covalent inhibitors of SmTGR, presenting antischistosomal efficacy in an animal model of infection, were developed targeting the doorstop pocket (here site S3), which further validates this pocket as a druggable site 96

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Further details regarding the reactions identified by the algorithm are available in Supplementary Data 5

however, most tissues contain vitamin C at much higher concentrations, ranging from 15 mM, and neurons contain vitamin C at concentrations of 10 mM or greater (Higdon et al