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Tpp-Met@MnO 2 @Alb doubly ameliorates tumor hypoxia by generating oxygen from MnO 2 and reducing oxygen consumption by Tpp-Met (Fig

A mixture of depressant and stimulant effects is noted at low doses

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Venglustat , a brain penetrant small molecule inhibitor of glycosylceramide synthase has failed to show an effect on progression of MDS-UPDRS part II+III scores after 52 weeks of treatment in a double-blind, placebo-controlled trial despite evidence for target engagement, i.e