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An anti-tumor abundant immune-infiltrate, indicated by high CD8 + T-lymphocytes and low T-regulatory cells, is a strong predictor of good response to chemotherapy in breast cancer patients [52, 53], suggesting that part of the anti-tumor effects of anthracyclines is mediated by the engagement of the host immune system

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Neurons exhibit a higher sensitivity to proteasome inhibition than astrocytes, mostly because they exhibit increased levels of oxidized proteins (Dasuri et al., 2010)

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This creates a gradient where theres high oxygen near the retina (which is very active) and low oxygen near the lens (which is sensitive to oxygen damage)