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It exceeds the predicted energy demand [20]

Also, KD is not entirely free of side effects, with fatigue, muscle cramps, hypotension, constipation, and unwanted weight loss being the most commonly reported (125)

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A study conducted on 100 CAD patients demonstrated a significant reduction in CRP levels in the L-carnitine group after 12 weeks of supplementation compared to baseline (Singhai et al

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However, whether it is harmful or beneficial for subjects with mild cardiovascular diseases or even those without clinical manifestations is still controversial, likely because of the following reasons: (i) similar strains of mice in different studies from different suppliers differ in baseline bacterial gut microbiome, diet (e.g., different choline levels), age of the mice, animal housing conditions, and duration of the experiment