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Moreover, inflammatory cytokines have been found to disrupt iron homeostasis in chondrocytes by upregulating transferrin receptor 1 (TfR1) and downregulating the iron transporter ferroportin (FPN), contributing to iron overload (Ni et al., 2020

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Overall, in vitro models reveal the strong context dependency of EV-based interventions, showing that EV effects on ovarian cells are highly sensitive to dose, exposure time, EV source, and the applied stress or aging paradigm

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In: Agrawal, D., Dhanasekaran, M

Increased sensitivity of hair follicles toward DHT leads to stunted hair growth