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Among the myriad consequences associated with social isolation, changes in liver function have attracted much attention 18

doi: 10.1016/j.colsurfa.2025.137049 [DOI] [Google Scholar] 212.Karim W, Kleibert A, Hartfelder U, et al

MEK1/2 phosphorylates and activates ERK1/2, and activated ERK phosphorylates ribosomal S6 kinase (RSK), serum response factor (SRF), E26 transformation-specific transcription factors (ETS) and ETS like-1 protein to regulate the transcription and translation of corresponding target genes, thus participating in the regulation of cell proliferation, differentiation, migration and other life activities 44,45,46

Pegylated arginase has potential arginine degradation and antitumor activity

These include oral tablets that work best on an empty stomach, intravenous infusions lasting 15-20 minutes, topical applications, and inhalants

Research shows that nicotine activates nAChRs on dopaminergic neurons, which are crucial for regulating neurotransmitter release and neuronal excitability (Quik et al., 2008)