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& Fletcher, J

Finally, unilateral orchidectomy, although adopted to reduce animal use and allow intra-subject comparison, may influence hormonal balance and induce compensatory changes in the contralateral testis

This use was associated with the production of short-chain fatty acids, such as acetate 40

These hallmark abnormalities disrupt synaptic communication, trigger neuroinflammation, and promote neuronal apoptosis, collectively leading to extensive neurodegeneration and cognitive dysfunction