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Colchicine is a natural alkaloid compound derived from Colchicum autumnale [27] that was initially used as an effective compound for the treatment of gout and familial Mediterranean fever (FMF), and its pharmacokinetics have been well studied [28]

[DOI] [Google Scholar] 188.Gupta S., Seth C.S

Adibi M, Thomas AZ, Borregales LD, Merrill MM, Slack RS, Chen HC, Sircar K, Murugan P, Tamboli P, Jonasch E, Tannir NM , Matin SF, Wood CG, Karam JA

Inhibiting DNA methylation by 5-aza-2-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation

MMPs are enzymes that break down extracellular matrix (ECM) components in the skin under both normal and diseased conditions