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In the cryo-EM structure of human ME2 without the inhibitor, the sample was purified in the absence of the cofactors NAD + , and only one NAD + molecule is observed in the exo site of the ME2 subunit (Figs

03 Research Highlights Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade 04 Dosage Administration & Timing Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue

Preclinical safety evaluation of biotechnology-derived pharmaceuticals

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