acetaminophen glutathione toxicity Paracetamol Silymarin prevents acetaminophen-induced hepatotoxicity via

Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors N Acetylcysteine & Paracetamol Poisoning Rescue 10 days of MCQ! Day 3: Acetaminophen Overdose Answer: C N acetylcysteine (NAC) NAC is the antidote for acetaminophen overdose. It works by replenishing hepatic glutathione stores, which are rapidly depleted Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology

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