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The conformational preferences were determined experimentally using either the cysteine accessibility experiments or by comparing binding affinity to specific mutants that shift the conformational state

Let's take a closer look at these features: Follicle Contraction: During the catagen phase, the hair follicles contract, causing the hair shaft to detach from the blood supply that nourishes it

This hardwired regulatory mechanism together with the observation that only the simultaneous depletion of these three FOXO isoforms results in a cancer phenotype in mice [32, 113] clearly points to redundant tumor suppressor functions of these proteins in cancer

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