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197 For instance, increased blood urea concentrations can alter the microbiome, resulting in the increased generation of toxic metabolites from the gastrointestinal tract as well as an increased tendency for toxins to cross the gut barrier, which can promote further kidney injury

180 In a randomized controlled trial, a 6-month graduated walking program, which increased in duration and intensity over the course of the program, improved not only obstructive sleep apnea severity and oxygen desaturation, but was associated with significant reductions in cholesterol levels

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This treatment is recommended for patients diagnosed as LQTS who are asymptomatic with QTc 470 ms and symptomatic for syncope or documented ventricular tachycardia/ventricular fibrillation 34,62,63