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In vivo subcellular mass spectrometry enables proteo-metabolomic single-cell systems biology in a chordate embryo developing to a normally behaving tadpole (X

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Overall, our results pinpoint the two-years mark as a point of significant stabilization for the gut microbiome, without precluding the further occurrence of important changes in the relative abundance of specific taxa and gene functions both before and after adolescence

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This leads to lower energy levels

Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning