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Lin J, Jia S, Cao F, Huang J, Chen J, Wang J, Liu P, Zeng H, Zhang X, Cui W

Bile acid metabolites control TH17 and Treg cell differentiation

Most studies identify a miRNA or protein switch (miR-138-5p, miR-21a-5p, miR-99b-3p, miR-421-3p, 14-3-3, resveratrol) that ultimately suppresses the PI3K/AKT/mTOR axis or liberates core autophagy genes (ATG7, Beclin-1)

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and (ii) decrease in production of free radicals via antagonism of the transition state of active metals [101]

Given the differential effects of ML226 on 2-OGDD inhibition, we wanted to take an orthogonal approach to impairing OGDHc activity