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doi: 10.1194/jlr.RA119000592 [DOI] [PMC free article] [PubMed] [Google Scholar] 295

Alvarez et al., 2013

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S6K1 has the ability to phosphorylate the insulin receptor and reduce its sensitivity to insulin in a negative feedback loop on mTORC1 signaling

The clinical judgment of the treating physician should guide the management plan of each patient based on individual benefit/risk assessment [see Adverse Reactions (6.1)]