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The efficacy evidence for edaravone is primarily derived from clinical trials in East Asian populations, and its benefits have been less consistently replicated in Western studies and real-world settings outside of Japan

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THNH PHN - Water, Butylene Glycol, Glycerin, Niacinamide (5000mg), Bis-PEG-18 Methyl Ether Dimethyl Silane, 1,2-Hexanediol, Glutathione (700mg), Kojyl Carboxy Dipeptide-23, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Extract, Milk Protein Extract, Punica Granatum Fruit Extract, Cornus Officinalis Fruit Extract, Centella Asiatica Extract, Rosa Damascena Flower Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Hippophae Rhamnoides Fruit Extract, Rosa Canina Fruit Extract, Zanthoxylum Piperitum Fruit Extract, Usnea Barbata (Lichen) Extract, Pulsatilla Koreana Extract, PEG-60 Hydrogenated Castor Oil, Adenosine, Xanthan Gum, Disodium EDTA, Ethylhexylglycerin, Caprylyl Glycol, Fragrance

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It was shown that high temperature (35 C) leads to no flowering, whereas in the temperature range from 20 to 30 C the hypericin content of flowers changed from 0.6 to 1.2 mg/g fresh weight 38