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Patients may be required to: Enroll in a pregnancy prevention program (e.g., iPLEDGE in the U.S.) Undergo regular blood tests (lipids, liver enzymes, CBC) Avoid donating blood during and for 1 month after treatment Practice strict contraception (if applicable) Stop taking certain medications or supplements that may interact Possible Side Effects While Isotretinoin 5 mg Capsules reduce the risk of high-dose side effects, some may still occur, including: Dry skin and lips Muscle or joint pain Temporary worsening of acne Nosebleeds Fatigue Eye dryness or irritation Rare but serious effects may involve mood changes, liver abnormalities, or increased triglycerides

Many patients note smoother texture by week 4

[Abstract] Nat Cell Biol

A.Mouatt-PrigentA.et al (2001)