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That is, xCT inhibitors may exhibit anticancer properties against cancer cells with elevated GLUT1 expression in a high-glucose tumor environment, whereas glucose deprivation blocks ferroptosis-induced cell death [18,19] [Figure 2B]

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Science 263 , 16291631 (1994)

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In addition, the gain-of-function Pik3ca H1047R mutant outcompetes normal esophageal cells in vivo, consistent with Pik3ca deletion reducing cell fitness 34