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Immunohistochemical evaluation of neuropathology The brain sections were cut to 40 m via frozen sectioning using a Leica SM2010R sliding microtome (Leica Biosystems, Deer Park, IL, USA)

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Notably, the lactylation of the nonhistone protein YY1 in microglia has been identified as a key factor in retinal neovascularization, primarily through upregulating FGF2 expression [121]

These results validate the findings of the original development cohort (N=132, Figure 1 )

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