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2.5.3 Regulation of Oxidative Stress Oxidative stress in the brain plays a key role in the development of PD (155, 156), and results from an imbalance between reactive oxygen species (ROS) and the ability to scavenge reactive intermediates (157)

Deletion of Nox4 in the nuclei of alveolar epithelial cells significantly reduces intranuclear H 2 O 2 production (by over 80% compared with controls), thereby protecting mice from Pseudomonas aeruginosa -induced pneumonia injury

NOS uncoupling is a pathological state in which NOS shifts from producing NO to generating superoxide (O), an ROS

Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA(R)) defined sperm DNA and chromatin integrity

"Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle." Biochemical Pharmacology

These GAD-associated syndromes, all characterized by abnormal synaptic neurotransmission, comprise the GAD antibody-spectrum disorders (GAD-SD) or SPS-SD since SPS remains the hallmark disease among all of them, although one or more of these disorders coexists in approximately 70% of patients with GAD65 neurological autoimmunity [3, 6,7,8,9, 30,31,32,33,34,35,36,37,38]