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It is less frequent in hepatic and pre-/asymptomatic patients (39)

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The investigators reported no adverse events and no measurable effect on tested biomarkers

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To provide further compelling evidence that SP inhibits the cGAS-STING pathway by suppressing the release of mtDNA, we employed EtBr at a concentration of 1.0 g/mL for 48 h to block mtDNA replication, which contributed to a reduced copy number of ND1 and ND2 , confirming the successful depletion of mtDNA (Figure 7F, G)