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a ) Volcano plot of differentially expressed analytes between sample 1 (T1) and sample 2 (T2) following deterioration of clinical symptoms in hospitalised patients

Some individuals report transient flushing, headache, or water retention during initial titration

It circulates in your blood, saliva, and urine, and it plays a central role in tissue repair, collagen production, and wound healing

146,147 UC patients have been shown to have significantly diminished gut microbiota diversity, with an increase in the abundance of harmful bacteria and a decrease in the abundance of beneficial bacteria, which affects the immune regulation and inflammatory response of the gut, thereby exacerbating symptoms and promoting the progression of the disease

Wu X, Chen X, Zhou Q, Li P, Yu B, Li J et al

The functioning of the IEB depends on the presence of a series of intercellular junctions composed by the apical junctional complex (AJC), including tight junctions (TJs) and adherens junctions (AJs), and desmosomes