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B12 supplements are generally recognized as safe AT ANY DOSE (SOURCE), but some supplements contain other nutrients like folic acid (which help B12 metabolize, but you dont want too much in synthetic form), so you should only take the recommended dose unless your doctor or pharmacist says otherwise

Those who are pregnant, nursing, under 18, or have kidney conditions should consult a doctor before use

They discovered that: NNMT is found in fat cells and other tissues that regulate metabolic pathways and fat storage

Its most important known metabolic function is to transport long chain fatty acids into the mitochondria of muscle cells for oxidation

Freiesleben, S

Cannon AM, et al