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The liver, which houses the highest glutathione concentrations and performs extensive detoxification work, increases its activity during sleep when digestive demands are minimal and energy can be directed toward cellular maintenance

[Abstract]2024 Sep 27;15(10):1266

Vitamin D, through the VDR signaling pathway, offers consistent antioxidant and immunomodulatory benefits in oral mucosal disorders, with minimal adverse effects, making it a promising adjunct in managing inflammatory and neoplastic oral lesions (89, 90)

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Gao and colleagues described the role of autophagy in CDI ferroptosis and emphasized that while genetic blockade of autophagy completely prevents ferroptosis, pharmacological inhibitors such as bafilomycin A1 and chloroquine are only effective at an earlier stage of ferroptosis [48]

Insufficient perfusion of blood and oxygen diffusion within the tumor microenvironment further exacerbate hypoxia, thereby promoting tumor expansion