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In 2017, worldwide antibiotic consumption reached 93 million tons (Tiseo et al., 2020), and projections indicate that this figure could exceed 236 million tons by 2030, with aquaculture contributing approximately 5.7% of that total (Schar et al., 2020)

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Adjustments were made for patient demographics, hospital characteristics, modified Charlson Comorbidity index, etiology, and decompensation of liver disease

Rev Cardiovasc Med 4:S14-20 Fuccelli R, Fabiani R, Rosignoli P (2018) Hydroxytyrosol exerts anti-inflammatory and anti-oxidant activities in a mouse model of systemic inflammation

Finally, we discuss promising biomarkers derived from microbial, inflammatory, and erythrocyte pathways that may facilitate early diagnosis and the development of diseasemodifying therapies

However, upon administration of ATP, these activities returned to levels comparable to those observed in the healthy control group