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During PCOS progression, persistent inflammation also induces mitochondrial dysfunction, uncouples the electron transport chain, and promotes substantial ROS leakage (75)

Heming M, Gran S, Jauch SL, Fischer-Riepe L, Russo A, Klotz L, Hermann S, Schfers M, Roth J, Barczyk-Kahlert K (2018) Peroxisome proliferator-activated receptor- modulates the response of macrophages to lipopolysaccharide and glucocorticoids