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Increased susceptibility in Hp knockout mice during acute hemolysis

1 Even with enzyme activity that is substantially reduced, there may be few or no clinical symptoms

The highest thiolate oxidizability of GSH (383 mV) belongs to the microspecies in which all other basic sites in the molecule are in non-protonated form

SOD1 disulfide bond formation and Cu + binding at the active site expel the stabilising CCS D3 hairpin from the SOD1CCS interface [51] and disrupt hydrogenbonding interactions between CCS D2 Arg232 and the SOD1 GDNT motif

The new vessels are also highly delicate and markedly permeable and may cause vision loss by intravitreal or pre-retinal (beneath the internal limiting membrane) hemorrhage