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Discussion Colistin is a cyclic heptapeptide with an acylated tripeptide side chain that exerts its antimicrobial activity by disrupting the integrity of the bacterial membrane and increasing its permeability, leading to leakage of the cell content, membrane depolarization and cell death 1

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[DOI] [PubMed] [Google Scholar] Tennison MB, Miles MV, Pollack GM, Thorn MD, Dupuis RE