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Tissue distribution favors areas with high GLP-1 and GIP receptor expression: pancreas, gut, brain, and adipose tissue

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Monitoring and Assessment Regular monitoring during IVIG therapy includes: Pain and symptom scores Quality of life measurements Repeat neurological examinations Sometimes repeat skin biopsies to assess nerve fiber density Blood tests for kidney function, blood counts, and immunoglobulin levels Potential Side Effects and Considerations While generally well-tolerated, IVIG can cause side effects including: Headache and flu-like symptoms Infusion site reactions Allergic responses Thromboembolic events (blood clots) Aseptic meningitis (rare) Renal dysfunction (particularly with pre-existing kidney issues) Patients with certain conditions, such as IgA deficiency, cardiac disease, or renal impairment, require special considerations before initiating IVIG

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