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According to Li et al., mitochondrial oxidative damage was brought on by erastin, an established inducer of ferroptosis

The First Enzymatic Step in Mercapturic Acid Formation, The Journal of Biological Chemistry , Vol

Kwon, D.R

In vivo experiments indicated that AGNHP inhibits ROS, LPO, and Fe 2+ accumulations in MCAO and ICH rats ( in vitro experiments shown that AGNHP mitigated ferroptosis damage caused by erastin in PC12 cells, enhanced cell survival, decreased LPO and Fe 2+ concentrations, and boosted mRNA expressions of PPAR, AKT, and GPX4 ( Di-Huang-Yin-Zi (DHYZ) is a traditional herbal medicine employed for the prevention and treatment of neurological disorders since the Song Dynasty

J Pharmacol Exp Ther (2011) 339:50918.10.1124/jpet.111.185694 135 KawasLHMcCoyATYamamotoBJWrightJWHardingJW

PEM is most common in developing nations, the elderly, hospitalized individuals, and those with chronic disease that interferes with nutrient absorption and utilization