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Genetic variation and heavy metals toxicities can greatly limit these factors, and necessitate glutathione supplementation to restore adequate levels

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10.1128/IAI.71.3.1442-1452.2003 77

Some small human trials mostly in PBC and insulin resistance show encouraging results, while larger, more definitive studies are still missing.4 6 In other areas, like amyotrophic lateral sclerosis (ALS) and neuroprotection, the story is even less clear: despite promising preclinical data, a recent Phase 3 ALS trial failed to confirm meaningful benefit.23 24 To help make sense of this, weve summarized the potential benefits of TUDCA in the chart below