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Many studies only indirectly demonstrate a link between cuproptosis and cancer, 363,447,505,506,507 leaving unclear whether these genes play a direct role in this relationship or if they are influenced indirectly

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Rogan 1,2 1 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA 2 Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-4388, USA Abstract Endogenous estrogens become carcinogens when excessive catechol estrogen quinone metabolites are formed

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