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Eli Lilly and Company Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial

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These reactions were dose-dependent, with higher doses producing more frequent and sometimes more pronounced reactions

Let us start with the brainstem

Ruff D, Crockford D, Girardi G, Zhang Y

Using a nasal spray eliminates the need for reconstitution, and dosing is straightforward with the metered spray format