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Anupam Bishayee, Seyed Mohammad Nabavi, Stphane Zingue, and Roja Rahimi reviewed and revised the manuscript

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It was hypothesized that such expansion might have occurred during adaptation to environmental selection pressure

Unlike beta-1 receptors in cardiac tissue or beta-2 receptors in smooth muscle, beta-3 receptors are predominantly expressed in adipose tissue and bladder, with limited cardiovascular effects

Can J Physiol Pharmacol 88(3):369378 Shan W-J, Huang L, Zhou Q, Meng F-C, Li X-S (2011) Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-beta aggregation

The fix: maintain a strict 15 to 30 minute food and drink window on both sides of administration