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It makes perfect sense physiologically starting with optimal hydration and nutrient levels gives your body a fighting chance against alcohol's effects

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Detoxification Support: Participates in phase II conjugation and helps neutralize reactive electrophiles in metabolic studies

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Butterfield LH, Merino A, Golub SH, Shau H

The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat Paracetamol (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis