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Methods Animals Ethical permission for mouse experiments was reviewed and approved by the Welcome Sanger Institute Ethics Committee and experiments conducted according to UK Government Home Office project licenses PPL22/2282, PPL70/7543 and PPL4639B40

Sleep quality is typically the first noticeable change

Synthesis of a new strand can only begin from a primer with the 3-OH end

Briefly, crude protein extracts were prepared using glass beads

Mol Cell Oncol 2020;7:1699375

[8] Sermorelin's effects are regulated by negative feedback through the inhibitory hormone somatostatin, making it difficult to overdose, unlike exogenous rhGH (a synthetic version of human GH)