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Pro-inflammatory cytokine receptors are highly aggregated in regions associated with cognitive functioning such as the hippocam-pus.4546 Pro-inflammatory cytokines and their receptors may inhibit neurogenesis and impair cognitive function.4748 Numerous reports have supported the idea that several pro-inflammatory cytokines affect neurogenesis

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Although HMB can stimulate MPS and reduce MPB, several systematic reviews and meta-analyses have shown that HMB supplementation does not increase or prevent loss of muscle mass [35, 54,55,56]

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