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J Exp Biol 207:31313139 Niu Y, Zhang X, Xu T, Li X, Zhang H, Wu A, Storey KB, Chen Q (2022) Physiological and biochemical adaptations to high altitude in Tibetan frogs, Nanorana parkeri

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Researchers observed that intra-articular administration was associated with changes in cartilage matrix composition and chondrocyte activity markers in the treated joints compared to controls [3]

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Still, most evidence behind BPC 157 comes from laboratory and animal research rather than large human studies