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The most common method, also introduced by Schilling, is to inject a high dose of unlabeled B12 to saturate all binding capacities of the B12 binding proteins, and thereby facilitating urinary excretion of the absorbed radioactively labeled B12

In contrast, nutritional capsules, though presumed harmless, lack FDA oversight and are not bound by strict safety and effectiveness regulations imposed on their production

A phase 2 trial reported a median survival of 20.4 months for people with pleural mesothelioma

2022 Jun;52(6):1219-1222

This stresses the need to pick the right Vitamin B12 injection for each patient