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In one embodiment, the counterion ion is the 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium cation (i.e., a tromethamine salt)

15 and Table 2)

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

LiWDingZZhangHShiQWangDZhangSet al

Typical research doses fall in the 100-300 mcg range per administration, with 1-3 administrations per research day depending on protocol design and endpoint measurements