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However, there is also a risk of rebound impact and variation of impact velocity, in turn limiting the accuracy of injury severity (Ma et al., 2019)

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A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)