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Egrifta remains the first and only FDA-approved GHRH analogue, and HIV-associated lipodystrophy remains its sole approved indication worldwide

Lerner et al

Trends also show interest in oral vs

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Expert Review Neurotherapeutics

sustained colony stimulating factor 1 (CSF-1) signaling keeps these cells within the lesion core, where they secrete extracellular matrix modulators that consolidate the glial scar and blunt axon regeneration, a barrier that can be partially lifted by delayed CSF-1 receptor inhibition (Stewart et al., 2025)