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These microbial alterations coincided with PTSD symptomatology, BBB dysfunction and hippocampal neuroinflammation, which was confirmed by increased proinflammatory cytokine levels IL-1 and IL-6 (Tanelian et al., 2023)

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206,207,208 ZnT3 exhibits predominant expression in the brain, particularly in key regions such as the hippocampus, amygdala, and cerebral cortex

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hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls

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Chemosphere 255, 126690

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These findings were surprising and contrasted with studies showing BPA-induced morphological differences

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(Souto et al., 2005) demonstrated an upregulation of NNMT expression in the WAT of individuals with IR or T2D

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