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M., Vogtlnder, N

About 30 years ago, Conrad Wagner and co-workers discovered that 5mTHF in the folate cycle binds to GNMT and lowers its activity

doi: 10.1038/bjc.2013.768 77 MelzerCvon derOheJLehnertHUngefrorenHHassR

Im pointing this out, not as criticism, but to make the point that our biochemistry shapes us is surprising ways

Clin Pharmacol Ther 90:707711 Wynne HA, Cope LH, Herd B, Rawlins MD, James OF, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man