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Considerations are based on IGF-1 biology, including its influence on growth factor signaling and metabolic regulation

doi: 10.4049/jimmunol.1501062 58 KaebischR.Mejas-LuqueR.PrinzC.GerhardM

Brain-derived neurotrophic factor and major depressive disorder: Evidence from meta-analyses

Scandinavian journal of rheumatology .1991;20(4):294-302

[121] found that cardiomyocyte expression of mitochondrial calcium uptake protein 1 (MICU1), a regulatory subunit of the MCU, was downregulated in db/db mice at 12 weeks of age, accompanied by mitochondria-dependent intrinsic apoptosis