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In addition, in restoring intestinal mechanical barrier function, PNS can alleviate intestinal mucosal barrier damage by increasing the expression of ZO-1, claudin-1, and occludin in colonic mucosal tissue (Lu et al., 2020)

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ROS can also influence tumor energy metabolism by regulating critical metabolic enzymes, skewing the tumor toward the pentose phosphate pathway to maintain its reducibility

Hesperidin (Matias et al., 2017), rutin (El-Sayed el et al., 2008), and rhamno (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

The interplay between inflammatory cells, mitochondrial dysfunction, and ROS production culminates in epithelial damage, a common feature portraying conditions like asthma [1316]