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In contrast, CB-839 showed no antitumor activity in PDAC mouse models due to the use of alternative metabolic pathways (e.g., fatty acid and lipid metabolism) by these cancer cells 45

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[DOI] [PubMed] [Google Scholar] Seidman MD, Khan MJ, Tang WX, Quirk WS

Acetate promotes T cell effector function during glucose restriction

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In 2018, the NCCD defined ferroptosis as a GPX4-dependent, iron-catalyzed lethal program triggered by intracellular redox imbalance and counteracted by lipid-soluble radical scavengers and iron-chelating agent (Galluzzi et al., 2018)